Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges
Identifieur interne : 003013 ( Main/Exploration ); précédent : 003012; suivant : 003014Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges
Auteurs : Sid E. O'Bryant [États-Unis] ; Simone Lista [France] ; Robert A. Rissman [États-Unis] ; Melissa Edwards [États-Unis] ; Fan Zhang [États-Unis] ; James Hall [États-Unis] ; Henrik Zetterberg [Suède, Royaume-Uni] ; Simon Lovestone [Royaume-Uni] ; Veer Gupta [Australie] ; Neill Graff-Radford [États-Unis] ; Ralph Martins [Australie] ; Andreas Jeromin [États-Unis] ; Stephen Waring [États-Unis] ; Esther Oh [États-Unis] ; Mitchel Kling [États-Unis] ; Laura D. Baker [États-Unis] ; Harald Hampel [France]Source :
- Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring [ 2352-8729 ] ; 2015.
Abstract
This study investigated the comparability of potential Alzheimer's disease (AD) biomarkers across blood fractions and assay platforms.
Nonfasting serum and plasma samples from 300 participants (150 AD patients and 150 controls) were analyzed. Proteomic markers were obtained via electrochemiluminescence or Luminex technology. Comparisons were conducted via Pearson correlations. The relative importance of proteins within an AD diagnostic profile was examined using random forest importance plots.
On the Meso Scale Discovery multiplex platform, 10 of the 21 markers shared >50% of the variance across blood fractions (serum amyloid A R2 = 0.99, interleukin (IL)10 R2 = 0.95, fatty acid-binding protein (FABP) R2 = 0.94, I309 R2 = 0.94, IL-5 R2 = 0.94, IL-6 R2 = 0.94, eotaxin3 R2 = 0.91, IL-18 R2 = 0.87, soluble tumor necrosis factor receptor 1 R2 = 0.85, and pancreatic polypeptide R2 = 0.81). When examining protein concentrations across platforms, only five markers shared >50% of the variance (beta 2 microglobulin R2 = 0.92, IL-18 R2 = 0.80, factor VII R2 = 0.78, CRP R2 = 0.74, and FABP R2 = 0.70).
The current findings highlight the importance of considering blood fractions and assay platforms when searching for AD relevant biomarkers.
Url:
DOI: 10.1016/j.dadm.2015.12.003
PubMed: 27019866
PubMed Central: 4802360
Affiliations:
- Australie, France, Royaume-Uni, Suède, États-Unis
- Angleterre, Californie, Caroline du Nord, Floride, Grand Londres, Maryland, Massachusetts, Minnesota, Oxfordshire, Pennsylvanie, Texas, Île-de-France
- Londres, Oxford, Paris
- Université d'Oxford
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wicri:level="2"><nlm:aff id="aff15">Texas Alzheimer's Research and Care Consortium, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Texas Alzheimer's Research and Care Consortium, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Oh, Esther" sort="Oh, Esther" uniqKey="Oh E" first="Esther" last="Oh">Esther Oh</name><affiliation wicri:level="2"><nlm:aff id="aff16">Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Kling, Mitchel" sort="Kling, Mitchel" uniqKey="Kling M" first="Mitchel" last="Kling">Mitchel Kling</name><affiliation wicri:level="2"><nlm:aff id="aff17">Behavioral Health Service, Cpl. Michael J. Crescenz VA Medical Center and Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Behavioral Health Service, Cpl. Michael J. Crescenz VA Medical Center and Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Baker, Laura D" sort="Baker, Laura D" uniqKey="Baker L" first="Laura D." last="Baker">Laura D. Baker</name><affiliation wicri:level="2"><nlm:aff id="aff18">Department of Medicine, Internal Medicine (Geriatrics), Wake Forest School of Medicine, Winston Salem, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Internal Medicine (Geriatrics), Wake Forest School of Medicine, Winston Salem, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation wicri:level="3"><nlm:aff id="aff2">AXA Research Fund & UPMC Chair, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AXA Research Fund & UPMC Chair, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) & Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpétrière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) & Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpétrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27019866</idno><idno type="pmc">4802360</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802360</idno><idno type="RBID">PMC:4802360</idno><idno type="doi">10.1016/j.dadm.2015.12.003</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002224</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002224</idno><idno type="wicri:Area/Pmc/Curation">002074</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002074</idno><idno type="wicri:Area/Pmc/Checkpoint">001108</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001108</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002575</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002575</idno><idno type="wicri:Area/PubMed/Curation">002507</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002507</idno><idno type="wicri:Area/PubMed/Checkpoint">002507</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002507</idno><idno type="wicri:Area/Ncbi/Merge">003333</idno><idno type="wicri:Area/Ncbi/Curation">003333</idno><idno type="wicri:Area/Ncbi/Checkpoint">003333</idno><idno type="wicri:Area/Main/Merge">003014</idno><idno type="wicri:Area/Main/Curation">003013</idno><idno type="wicri:Area/Main/Exploration">003013</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges</title><author><name sortKey="O Bryant, Sid E" sort="O Bryant, Sid E" uniqKey="O Bryant S" first="Sid E." last="O'Bryant">Sid E. O'Bryant</name><affiliation wicri:level="2"><nlm:aff id="aff1">Institute for Healthy Aging, Center for Alzheimer's & Neurodegenerative Disease Research, University of North Texas Health Science Center, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Healthy Aging, Center for Alzheimer's & Neurodegenerative Disease Research, University of North Texas Health Science Center, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Lista, Simone" sort="Lista, Simone" uniqKey="Lista S" first="Simone" last="Lista">Simone Lista</name><affiliation wicri:level="3"><nlm:aff id="aff2">AXA Research Fund & UPMC Chair, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AXA Research Fund & UPMC Chair, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) & Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpétrière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) & Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpétrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rissman, Robert A" sort="Rissman, Robert A" uniqKey="Rissman R" first="Robert A." last="Rissman">Robert A. Rissman</name><affiliation wicri:level="2"><nlm:aff id="aff4">Alzheimer's Disease Cooperative Study, Department of Neurosciences, UCSD School of Medicine, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alzheimer's Disease Cooperative Study, Department of Neurosciences, UCSD School of Medicine, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Edwards, Melissa" sort="Edwards, Melissa" uniqKey="Edwards M" first="Melissa" last="Edwards">Melissa Edwards</name><affiliation wicri:level="2"><nlm:aff id="aff5">Department of Psychology, University of North Texas, Denton, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, University of North Texas, Denton, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Zhang, Fan" sort="Zhang, Fan" uniqKey="Zhang F" first="Fan" last="Zhang">Fan Zhang</name><affiliation wicri:level="2"><nlm:aff id="aff6">Department of Molecular and Medical Genetics, University of North Texas Health Science Center, Fort Worth, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Medical Genetics, University of North Texas Health Science Center, Fort Worth, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Hall, James" sort="Hall, James" uniqKey="Hall J" first="James" last="Hall">James Hall</name><affiliation wicri:level="2"><nlm:aff id="aff1">Institute for Healthy Aging, Center for Alzheimer's & Neurodegenerative Disease Research, University of North Texas Health Science Center, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Healthy Aging, Center for Alzheimer's & Neurodegenerative Disease Research, University of North Texas Health Science Center, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff7">Department of Psychiatry, University of North Texas Health Science Center, Fort Worth, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of North Texas Health Science Center, Fort Worth, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Zetterberg, Henrik" sort="Zetterberg, Henrik" uniqKey="Zetterberg H" first="Henrik" last="Zetterberg">Henrik Zetterberg</name><affiliation wicri:level="1"><nlm:aff id="aff8">Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal</wicri:regionArea><wicri:noRegion>Mölndal</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff9">UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><affiliation wicri:level="4"><nlm:aff id="aff10">Department of Psychiatry, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychiatry, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Gupta, Veer" sort="Gupta, Veer" uniqKey="Gupta V" first="Veer" last="Gupta">Veer Gupta</name><affiliation wicri:level="1"><nlm:aff id="aff11">Center of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Faculty of Health, Engineering and Sciences, Edith Cowan University, Joondalup, WA, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Center of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Faculty of Health, Engineering and Sciences, Edith Cowan University, Joondalup, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Graff Radford, Neill" sort="Graff Radford, Neill" uniqKey="Graff Radford N" first="Neill" last="Graff-Radford">Neill Graff-Radford</name><affiliation wicri:level="2"><nlm:aff id="aff12">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Martins, Ralph" sort="Martins, Ralph" uniqKey="Martins R" first="Ralph" last="Martins">Ralph Martins</name><affiliation wicri:level="1"><nlm:aff id="aff11">Center of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Faculty of Health, Engineering and Sciences, Edith Cowan University, Joondalup, WA, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Center of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Faculty of Health, Engineering and Sciences, Edith Cowan University, Joondalup, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Jeromin, Andreas" sort="Jeromin, Andreas" uniqKey="Jeromin A" first="Andreas" last="Jeromin">Andreas Jeromin</name><affiliation wicri:level="2"><nlm:aff id="aff13">Quanterix Corp., Lexington, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Quanterix Corp., Lexington, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Waring, Stephen" sort="Waring, Stephen" uniqKey="Waring S" first="Stephen" last="Waring">Stephen Waring</name><affiliation wicri:level="2"><nlm:aff id="aff14">Essentia Institute of Rural Health, Duluth, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Essentia Institute of Rural Health, Duluth, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff15">Texas Alzheimer's Research and Care Consortium, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Texas Alzheimer's Research and Care Consortium, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Oh, Esther" sort="Oh, Esther" uniqKey="Oh E" first="Esther" last="Oh">Esther Oh</name><affiliation wicri:level="2"><nlm:aff id="aff16">Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Kling, Mitchel" sort="Kling, Mitchel" uniqKey="Kling M" first="Mitchel" last="Kling">Mitchel Kling</name><affiliation wicri:level="2"><nlm:aff id="aff17">Behavioral Health Service, Cpl. Michael J. Crescenz VA Medical Center and Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Behavioral Health Service, Cpl. Michael J. Crescenz VA Medical Center and Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Baker, Laura D" sort="Baker, Laura D" uniqKey="Baker L" first="Laura D." last="Baker">Laura D. Baker</name><affiliation wicri:level="2"><nlm:aff id="aff18">Department of Medicine, Internal Medicine (Geriatrics), Wake Forest School of Medicine, Winston Salem, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Internal Medicine (Geriatrics), Wake Forest School of Medicine, Winston Salem, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation wicri:level="3"><nlm:aff id="aff2">AXA Research Fund & UPMC Chair, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AXA Research Fund & UPMC Chair, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) & Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpétrière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) & Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpétrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring</title><idno type="eISSN">2352-8729</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>This study investigated the comparability of potential Alzheimer's disease (AD) biomarkers across blood fractions and assay platforms.</p></sec><sec><title>Methods</title><p>Nonfasting serum and plasma samples from 300 participants (150 AD patients and 150 controls) were analyzed. Proteomic markers were obtained via electrochemiluminescence or Luminex technology. Comparisons were conducted via Pearson correlations. The relative importance of proteins within an AD diagnostic profile was examined using random forest importance plots.</p></sec><sec><title>Results</title><p>On the Meso Scale Discovery multiplex platform, 10 of the 21 markers shared >50% of the variance across blood fractions (serum amyloid A R<sup>2</sup> = 0.99, interleukin (IL)10 R<sup>2</sup> = 0.95, fatty acid-binding protein (FABP) R<sup>2</sup> = 0.94, I309 R<sup>2</sup> = 0.94, IL-5 R<sup>2</sup> = 0.94, IL-6 R<sup>2</sup> = 0.94, eotaxin3 R<sup>2</sup> = 0.91, IL-18 R<sup>2</sup> = 0.87, soluble tumor necrosis factor receptor 1 R<sup>2</sup> = 0.85, and pancreatic polypeptide R<sup>2</sup> = 0.81). When examining protein concentrations across platforms, only five markers shared >50% of the variance (beta 2 microglobulin R<sup>2</sup> = 0.92, IL-18 R<sup>2</sup> = 0.80, factor VII R<sup>2</sup> = 0.78, CRP R<sup>2</sup> = 0.74, and FABP R<sup>2</sup> = 0.70).</p></sec><sec><title>Discussion</title><p>The current findings highlight the importance of considering blood fractions and assay platforms when searching for AD relevant biomarkers.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Loannidis, J P" uniqKey="Loannidis J">J.P. Loannidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Collins, F S" uniqKey="Collins F">F.S. Collins</name></author><author><name sortKey="Tabak, L A" uniqKey="Tabak L">L.A. Tabak</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Prinz, F" uniqKey="Prinz F">F. 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Ross</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Caroline du Nord</li><li>Floride</li><li>Grand Londres</li><li>Maryland</li><li>Massachusetts</li><li>Minnesota</li><li>Oxfordshire</li><li>Pennsylvanie</li><li>Texas</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Oxford</li><li>Paris</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="O Bryant, Sid E" sort="O Bryant, Sid E" uniqKey="O Bryant S" first="Sid E." last="O'Bryant">Sid E. O'Bryant</name></region><name sortKey="Baker, Laura D" sort="Baker, Laura D" uniqKey="Baker L" first="Laura D." last="Baker">Laura D. Baker</name><name sortKey="Edwards, Melissa" sort="Edwards, Melissa" uniqKey="Edwards M" first="Melissa" last="Edwards">Melissa Edwards</name><name sortKey="Graff Radford, Neill" sort="Graff Radford, Neill" uniqKey="Graff Radford N" first="Neill" last="Graff-Radford">Neill Graff-Radford</name><name sortKey="Hall, James" sort="Hall, James" uniqKey="Hall J" first="James" last="Hall">James Hall</name><name sortKey="Hall, James" sort="Hall, James" uniqKey="Hall J" first="James" last="Hall">James Hall</name><name sortKey="Jeromin, Andreas" sort="Jeromin, Andreas" uniqKey="Jeromin A" first="Andreas" last="Jeromin">Andreas Jeromin</name><name sortKey="Kling, Mitchel" sort="Kling, Mitchel" uniqKey="Kling M" first="Mitchel" last="Kling">Mitchel Kling</name><name sortKey="Oh, Esther" sort="Oh, Esther" uniqKey="Oh E" first="Esther" last="Oh">Esther Oh</name><name sortKey="Rissman, Robert A" sort="Rissman, Robert A" uniqKey="Rissman R" first="Robert A." last="Rissman">Robert A. Rissman</name><name sortKey="Waring, Stephen" sort="Waring, Stephen" uniqKey="Waring S" first="Stephen" last="Waring">Stephen Waring</name><name sortKey="Waring, Stephen" sort="Waring, Stephen" uniqKey="Waring S" first="Stephen" last="Waring">Stephen Waring</name><name sortKey="Zhang, Fan" sort="Zhang, Fan" uniqKey="Zhang F" first="Fan" last="Zhang">Fan Zhang</name></country><country name="France"><region name="Île-de-France"><name sortKey="Lista, Simone" sort="Lista, Simone" uniqKey="Lista S" first="Simone" last="Lista">Simone Lista</name></region><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><name sortKey="Lista, Simone" sort="Lista, Simone" uniqKey="Lista S" first="Simone" last="Lista">Simone Lista</name></country><country name="Suède"><noRegion><name sortKey="Zetterberg, Henrik" sort="Zetterberg, Henrik" uniqKey="Zetterberg H" first="Henrik" last="Zetterberg">Henrik Zetterberg</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Zetterberg, Henrik" sort="Zetterberg, Henrik" uniqKey="Zetterberg H" first="Henrik" last="Zetterberg">Henrik Zetterberg</name></region><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name></country><country name="Australie"><noRegion><name sortKey="Gupta, Veer" sort="Gupta, Veer" uniqKey="Gupta V" first="Veer" last="Gupta">Veer Gupta</name></noRegion><name sortKey="Martins, Ralph" sort="Martins, Ralph" uniqKey="Martins R" first="Ralph" last="Martins">Ralph Martins</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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